GABA-A receptor
Main function
GABA-A is one of the body's main systems for slowing activity in the brain and spinal cord. When activated by GABA it makes nerve cells less likely to send further signals, helping balance stimulating brain activity. It plays major roles in anxiety control, sleep, muscle tone, memory, coordination and protection against excessive brain activity and seizures. Many sedatives, sleep medications and anaesthetic drugs work partly by increasing GABA-A activity.
Main body locations
Positive and negative describe interaction direction, not whether an effect is good or bad. Activating a target can have unwanted effects, while reducing or blocking it can sometimes have beneficial effects.
Increased activity
Increased GABA-A activity can increase relaxation, reduce anxiety and excessive nerve activity, promote sleep, relax muscles and reduce the likelihood of seizures. Stronger activation can cause increasing drowsiness, slowed reactions, impaired coordination, reduced attention and short-term memory impairment. Very strong activation by powerful GABA-A drugs can produce profound sedation.
Reduced or blocked activity
Reduced or blocked GABA-A activity increases nerve activity and can increase anxiety, restlessness, sensitivity to stimulation and muscle tension. Strong inhibition can cause tremors, agitation and may increase the risk of seizures.
No linked substances yet.